Clinical Trial

Association of Periodontal Status and Smoking With Salivary Inflammasome Markers

Recruiting
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Record status
This record was last updated January 21, 2026 (before its estimated June 2026 completion). Its status may not reflect the trial's current state.
Summary
The aim of this study is to evaluate the relationship between periodontal status and salivary levels of the inflammasomes NOD-like receptor family, pyrin domain containing 3 (NLRP-3), NOD-like receptor family, pyrin domain containing 6 (NLRP-6), NOD-like receptor family, pyrin domain containing 12 (NLRP-12), NOD-like receptor family, CARD domain containing 5 (NLRC-5), interleukin-1 beta (IL-1β) and interleukin-10 (IL-10). Furthermore, this study aims to investigate whether the salivary levels of these inflammasomes may serve as potential diagnostic biomarkers for distinguishing individuals with periodontitis from those without. In addition, the potential role of smoking in modulating the relationship between periodontal status and salivary inflammasome levels will also be explored.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-12-16.
Trial Details
NCT Number NCT07312552
Lead Sponsor Uskudar University
Conditions Periodontitis, Periodontal Disease, Periodontal Health, Smoking, Inflammasomes
Enrollment 116 participants
Start Date 2025-12-23
Primary Completion 2026-06 (estimated)
Study Completion 2026-07 (estimated)
Updated on ClinicalTrials.gov 2026-01-21