Clinical Trial

Study on the Efficacy of Temporal Interference Stimulation (TIS) for Parkinson's Disease

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Record status
This record was last updated December 31, 2025 (before its estimated May 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
The primary objective of this clinical study is to evaluate the therapeutic efficacy of Temporal Interference Stimulation (TIS), a non-invasive deep brain stimulation technique, in patients with Parkinson's disease, and to further investigate its potential mechanisms of action. Although TIS offers lower stimulation intensity and precision compared to conventional Deep Brain Stimulation (DBS), it possesses the distinct advantage of being non-invasive. This study utilizes TIS to explore different stimulation targets analogous to those used in DBS for Parkinson's disease, thereby providing valuable insights for subsequent DBS surgical interventions. The findings will contribute preliminary exploratory evidence regarding the application of non-invasive deep brain stimulation technology in the treatment of Parkinson's disease.
Trial Details
NCT Number NCT07312279
Lead Sponsor Zhongnan Hospital
Conditions Temporal Interference Stimulation (TIS), Parkinson's Disease
Enrollment 24 participants
Start Date 2025-12-30
Primary Completion 2026-05-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-12-31