Virtual Reality - Gamma Sensory Stimulation for Improving Fatigue in People With Multiple Sclerosis

This is a double-blind, parallel, randomized, sham-controlled pilot study evaluating the safety, feasibility, and efficacy of Gamma Sensory Stimulation (GSS) delivered via a Virtual Reality (VR) headset in individuals with Multiple Sclerosis (MS) who experience moderate to severe fatigue. Participants will be randomized (1:1) to 4 weeks of active GSS or sham stimulation, followed by a 4-week post-treatment follow-up. The primary objective is to determine whether GSS reduces fatigue, measured by the Modified Fatigue Impact Scale (MFIS). Secondary outcomes include additional fatigue scales, cognitive performance, quality-of-life measures, tolerability and safety.

NCT Number	NCT07310862
Lead Sponsor	Clarity Health Technologies, Inc Collaborators: Parc de Salut Mar
Conditions	Multiple Sclerosis
Enrollment	30 participants
Start Date	2026-03-01
Primary Completion	2027-03-01 (estimated)
Study Completion	2027-04-01 (estimated)
Updated on ClinicalTrials.gov	2026-02-03