Comparison of Mirabegron and Tamsulosin for Ureteral Stone Expulsion

This randomized controlled trial compares the efficacy and safety of four treatment strategies for ureteral stone expulsion: Mirabegron alone, Tamsulosin alone, a combination of both, and standard conservative care. Participants diagnosed with ureteral stones will be randomly assigned to one of these four groups. The primary objective is to evaluate the stone expulsion rate within 4 weeks. The study also assesses time to expulsion, pain intensity, analgesic use, and potential side effects.

NCT Number	NCT07310797
Lead Sponsor	Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Conditions	Ureteral Calculi
Enrollment	500 participants
Start Date	2026-02-13
Primary Completion	2029-12-31 (estimated)
Study Completion	2030-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-08