External Validation of the CLOVER Score for Detecting Occult Cancer in Venous Thromboembolism Patients

This study aims to externally validate the CLOVER score, a machine learning-based predictive model designed to identify patients with venous thromboembolism (VTE) who are at increased risk of having an occult cancer. The study includes a retrospective cohort of patients with acute symptomatic VTE diagnosed between 2000 and 2022, and a prospective cohort of consecutively recruited patients from December 2025 to December 2027. The CLOVER model will be applied to all participants, and its ability to discriminate between patients with and without occult cancer will be evaluated. The study also assesses clinicians' satisfaction with the web-based tool (CLOVER-Web) developed to facilitate the use of the score in clinical practice.

NCT Number	NCT07310693
Lead Sponsor	Infanta Leonor University Hospital Collaborators: Fundación para la Investigación e Innovación Biomédica del Hospital Universitario Infanta Leonor
Conditions	Venous Thromboembolism (VTE), Occult Cancer
Enrollment	500 participants
Start Date	2025-12-01
Primary Completion	2028-12-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-30