Clinical Trial

Comparison of Analgesic Efficacy of Intrathecal Levobupivacaine With and Without Oral Tizanidine in Lower Limb Surgeries: A Prospective Randomized Study

Completed Phase 4
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Summary
Tizanidine, alpha-2 adrenergic receptor agonist, provides analgesic and hemodynamic benefits, which could enhance the efficacy of local anaesthetics. This randomized controlled trial examines the effectiveness of oral tizanidine as an adjunct to intrathecal levobupivacaine for spinal anaesthesia in lower limb surgeries
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-12-20.
Trial Details
NCT Number NCT07310628
Lead Sponsor All India Institute of Medical Sciences
Collaborators: All India Institute of Medical Sciences, Raebareli, UP
Conditions Tizanididne, Levobupicaine, Lower Limb Surgery, Pain, Chronic
Enrollment 64 participants
Start Date 2022-08-20
Primary Completion 2025-07-10 (estimated)
Study Completion 2025-08-20 (estimated)
Updated on ClinicalTrials.gov 2026-01-09