Postoperative Hypoxemia Increases the Risk of Anastomotic Leak After Radical Esophagectomy

This study aims to determine whether postoperative hypoxia (arterial partial pressure of oxygen (PaO₂)\<80 mmHg) is an independent risk factor for anastomotic leakage after esophagectomy. The investigators conducted a retrospective analysis of cases from their center over the past five years, stratifying patients into Low Pa0₂ Group and Normal Pa0₂ Group based on postoperative oxygen levels and comparing the incidence of anastomotic leakage between the groups. The goal is to establish whether hypoxia is a causative risk factor and whether correcting it can reduce the risk of anastomotic leakage.

NCT Number	NCT07309991
Lead Sponsor	Sun Yat-sen University Collaborators: Sichuan Cancer Hospital and Research Institute, Affiliated Hospital of North Sichuan Medical College, Hebei Medical University Fourth Hospital, Affiliated Cancer Hospital of Shantou University Medical College, Shanghai Chest Hospital
Conditions	Esophageal Carcinoma, Esophageal Adenocarcinoma, Esophagectomy, PaO2, Esophageal Anastomotic Leakeage
Enrollment	2,500 participants
Start Date	2021-01-01
Primary Completion	2025-12-01 (estimated)
Study Completion	2026-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-16