MPR for Stroke Risk Assessment of ICAS

Intracranial atherosclerotic stenosis (ICAS) carries substantial stroke risk despite optimal medical treatment. Current risk stratification relies primarily on stenosis severity, but novel hemodynamic markers may improve prediction. In this multiple prospective registry study we aim to investigate whether regional hemodynamics, measured by a novel Magnetic resonance imaging-derived Pressure Ratio (MPR) technique, are associated with stroke risk in ICAS.

NCT Number	NCT07309718
Lead Sponsor	Xuanwu Hospital, Beijing Collaborators: Xuanwu Hebei Hospital, Xuanwu Xiongan Hospital, Xuanwu Chifeng Hospital, Xuanwu Jinan Hospital
Conditions	ICAS - Intracranial Atherosclerosis, Stroke Ischemic, Hemodynamic
Enrollment	400 participants
Start Date	2025-12-01
Primary Completion	2027-12-15 (estimated)
Study Completion	2028-03-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-30