Individual Differences in Gait and Osteoarthritis Pain

The goal of this observational study is to look at inter-individual differences in knee osteoarthritis (OA) walking pain and performance. The main questions this study aims to answer are: Why do some people with knee osteoarthritis have more severe disabling pain than others, even though the degenerative changes in their knees are similar? What are the factors that contribute to walking pain in people with knee osteoarthritis? Participants will complete surveys, perform physical function tasks, get a knee X-ray and MRI, undergo non-invasive brain imaging, and undergo sensory testing.

NCT Number	NCT07308873
Lead Sponsor	University of Pittsburgh Collaborators: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Conditions	Knee Osteoarthritis (OA), Chronic Pain, Chronic Knee Pain
Enrollment	300 participants
Start Date	2026-01-07
Primary Completion	2030-08-01 (estimated)
Study Completion	2030-08-01 (estimated)
Updated on ClinicalTrials.gov	2026-01-29