Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery

For patients after surgery, quality of recovery has significant impacts on the prognosis, quality of life, and rational allocation of medical resources. Dexmedetomidine and esketamine have each been used during the perioperative period and improved postoperative analgesia and subjective sleep quality. This 2x2 factorial trial is designed to explore the effects of dexmedetomidine, esketamine, and their combination on the quality of recovery in patients recovering from surgery under general anesthesia.

NCT Number	NCT07308756
Lead Sponsor	Peking University First Hospital
Conditions	General Anesthesia, Surgery, Dexmedetomidine, Esketamine, Quality of Recovery
Enrollment	316 participants
Start Date	2026-01-05
Primary Completion	2027-03 (estimated)
Study Completion	2027-04 (estimated)
Updated on ClinicalTrials.gov	2026-04-13