Computed Tomography-derived Fractional Flow Reserve vs. Angiographic Quantitative Flow Ratio in Management of Patients With Coronary Artery Disease

This is a multi-center, randomized controlled trial to compare the clinical outcomes between CT-derived fractional flow reserve (CT-FFR) guided strategy and angiography-derived quantitative flow ratio (QFR) guided strategy among patients with coronary artery disease (CAD). Participants who have at least one coronary stenosis of 70%-90% (vessel diameter ≥2.5 mm) detected by coronary CT angiography will be enrolled and are randomly assigned in a 1:1 ratio to CT-FFR guided group or QFR guided group. In CT-FFR group, the decisions of invasive angiography and revascularization will be guided by CT-FFR. In QFR group, the decision of invasive angiography will be made as usual care, and revascularization will be guided by QFR. The primary endpoint is the 1-year incidence of major adverse cardiac events (MACEs), including death, myocardial infarction, and unplanned revascularization.

NCT Number	NCT07308496
Lead Sponsor	China National Center for Cardiovascular Diseases Collaborators: Fuwai Yunnan Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Shenzhen Sun Yat-sen Cardiovascular Hospital, Ruijin Hospital, Nanjing First Hospital, Nanjing Medical University, The First Affiliated Hospital with Nanjing Medical University, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, The First Affiliated Hospital of Dalian Medical University, Chinese Academy of Medical Sciences, Fuwai Hospital
Conditions	Coronary Artery Disease
Enrollment	1,402 participants
Start Date	2026-03-01
Primary Completion	2028-07-01 (estimated)
Study Completion	2028-07-01 (estimated)
Updated on ClinicalTrials.gov	2026-02-12