Clinical Trial

The Influence of Gut Microbiota on Ovarian Function: A Single-center, Randomized,Double Blind, Parallel-controlled, Exploratory Clinical Trial

Active, Not Recruiting Early Phase 1
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Record status
This record was last updated December 29, 2025 (before its estimated December 31, 2025 completion). Its status may not reflect the trial's current state.
Summary
In order to study the community profile of the intestinal microbiome in women with ovarian dysfunction, as well as the relationship between the changes in the intestinal microbiota and sex hormones, this study recruited 30 women with ovarian dysfunction and 30 healthy women. Sequencing was performed on the V3-V4 region of the 16S rDNA gene in fecal samples, and blood serum of the patients was collected for the study of changes in the systemic metabolome to reveal the significant differences in the intestinal microbiota between the subjects with ovarian dysfunction and the control group, as well as the related metabolic pathways.
Trial Details
NCT Number NCT07308327
Lead Sponsor Songling Zhang
Conditions Premature Ovarian Failure (POF)
Enrollment 60 participants
Start Date 2025-03-01
Primary Completion 2025-12-31 (estimated)
Study Completion 2025-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-12-29