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Early Statin-Ezetimibe Combination vs. Statin Monotherapy in Stroke With Atherosclerosis

StatusRecruiting
PhasePhase 2
Started2025-08-01
View on ClinicalTrials.gov ↗

Amendment history

2025-12-28
minor
Study Status, Eligibility v1
Eligibility criteriarevised
[...] ssigned medication within 2 days of randomization; (3) aged 4020 years or older; (4) LDL-C ≥ 100 mg/dL after index ischemic [...]
2025-12-15
minor
Original filing
This study will be conducted at six medical institutions in Taiwan, recruiting patients who visit neurology outpatient clinics or are hospitalized within 30 days after an ischemic stroke. Participants will be randomly assigned to either the experimental group (moderate-intensity statin plus ezetimibe) or the control group (moderate- or high-intensity statin). Research assistants will screen patients aged 40 or older who have had an ischemic stroke or transient ischemic attack within 30 days, have atherosclerosis, and have LDL-C levels ≥100 mg/dL. Eligible cases will be reviewed by the attending physician. With physician approval, patients will be invited to join the study, and those who agree and sign informed consent will be enrolled.
Trial Details
NCT Number NCT07307989
Lead Sponsor Chang Gung Memorial Hospital
Collaborators: Chang Gung University
Conditions Ischemic Stroke, Hypercholesteremia
Enrollment 300 participants
Start Date 2025-08-01
Primary Completion 2029-07-31 (estimated)
Study Completion 2029-07-31 (estimated)
Updated on ClinicalTrials.gov 2025-12-30