Early Statin-Ezetimibe Combination vs. Statin Monotherapy in Stroke With Atherosclerosis

This study will be conducted at six medical institutions in Taiwan, recruiting patients who visit neurology outpatient clinics or are hospitalized within 30 days after an ischemic stroke. Participants will be randomly assigned to either the experimental group (moderate-intensity statin plus ezetimibe) or the control group (moderate- or high-intensity statin). Research assistants will screen patients aged 40 or older who have had an ischemic stroke or transient ischemic attack within 30 days, have atherosclerosis, and have LDL-C levels ≥100 mg/dL. Eligible cases will be reviewed by the attending physician. With physician approval, patients will be invited to join the study, and those who agree and sign informed consent will be enrolled.

NCT Number	NCT07307989
Lead Sponsor	Chang Gung Memorial Hospital Collaborators: Chang Gung University
Conditions	Ischemic Stroke, Hypercholesteremia
Enrollment	300 participants
Start Date	2025-08-01
Primary Completion	2029-07-31 (estimated)
Study Completion	2029-07-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-30