Real-Time Algorithm-Driven Ventilation Feedback to Improve Lung-Protective Ventilation in Patients With ARDS (REALVENT-study)

The REALVENT trial is designed to evaluate whether a real-time, algorithm-driven ventilation feedback strategy can improve lung-protective ventilation (LPV) achievement rates in critically ill patients receiving invasive mechanical ventilation. This multicentre randomised controlled trial will compare real-time respiratory waveform monitoring with automated feedback against standard ICU care. The primary endpoint is the LPV achievement rate over the first 72 hours.

NCT Number	NCT07307066
Lead Sponsor	Peking Union Medical College Hospital Collaborators: Beijing Hepingli Hospital, Beijing No.6 Hospital, Jinzhou Medical University, Henan Provincial People's Hospital, Binzhou Second People's Hospital, Chongqing General Hospital, Qujing Central Hospital of Yunnan Province, Shandong Provincial Hospital, Capital Medical University Affiliated Beijing Anzhen Hospital, Nanchong Center
Conditions	ARDS (Acute Respiratory Distress Syndrome), VILI (Ventilator-induced Lung Injury), Respiratory Failure, Critical Illness
Enrollment	208 participants
Start Date	2025-12-30
Primary Completion	2026-12-30 (estimated)
Study Completion	2027-02-28 (estimated)
Updated on ClinicalTrials.gov	2026-07-01