Doxycycline vs. Macrolide for MRMP (DOMINO)

The goal of this clinical trial is to learn if doxycycline works to treat pneumonia in children. It focuses on children with Mycoplasma pneumoniae infection that may not respond to standard medicines. The main questions it aims to answer are: * Does doxycycline stop fevers faster than azithromycin? * Is doxycycline safe for children, specifically regarding tooth color changes? Researchers will compare doxycycline to azithromycin to see if doxycycline works better to treat this type of pneumonia. Participants will: * Take either doxycycline or azithromycin by mouth for 7 to 14 days. * Check their body temperature to see when their fever goes away. * Visit the hospital to check for any medical problems. * Have their teeth checked for color changes 28 days after starting the medicine.

NCT Number	NCT07306234
Lead Sponsor	Young June Choe Collaborators: Korea Society of Pediatric Infectious Diseases, National Institute of Health, Korea, Korea Disease Control and Prevention Agency, DT&CRO
Conditions	Mycoplasma Pneumoniae, Mycoplasma Pneumoniae Pneumonia
Enrollment	208 participants
Start Date	2026-03-01
Primary Completion	2029-01-31 (estimated)
Study Completion	2029-02-28 (estimated)
Updated on ClinicalTrials.gov	2025-12-29