Comparison of Early Caffeine Administration Vs Supportive Therapy in Preventing Acute Kidney Injury

Recent observational data point towards a reduced incidence of acute kidney injury (AKI) with early caffeine use, but high-quality randomized controlled trials comparing early caffeine initiation to supportive therapy alone are lacking. This study aims to fill this critical gap by comparing the efficacy of early caffeine administration versus supportive therapy in preventing AKI in preterm neonates.

NCT Number	NCT07305935
Lead Sponsor	Muhammad Aamir Latif
Conditions	Preterm Birth
Enrollment	236 participants
Start Date	2025-10-01
Primary Completion	2026-03-31 (estimated)
Study Completion	2026-03-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-22