Pilot Study for the Evaluation of a New Psychotherapeutic Treatment for Borderline Personality Disorder Patients With Post-traumatic Stress Symptoms

Borderline Personality Disorder (BPD) is a serious mental health condition that often co-occurs with Complex PTSD (CPTSD), making treatment more challenging. Trauma-Focused Mentalization-Based Treatment (MBT-TF) is a new adaptation of standard MBT designed for individuals with high trauma exposure. Early findings are promising, but further research is needed. This study at Geneva University Hospitals (HUG) will test the feasibility and acceptability of MBT-TF compared with standard MBT, gathering feedback from patients and clinicians and laying the groundwork for a larger clinical trial.

NCT Number	NCT07305155
Lead Sponsor	Eva Rüfenacht
Conditions	Borderline Personality Disorder (BPD), PTSD - Post Traumatic Stress Disorder
Enrollment	40 participants
Start Date	2026-06-01
Primary Completion	2030-09-01 (estimated)
Study Completion	2030-12 (estimated)
Updated on ClinicalTrials.gov	2026-02-06