Clinical Trial

Clinical and Genetic Aspects of Fetuses With Sex-chromosome Disorders

Enrolling by Invitation
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Summary
To conduct a comprehensive clinical investigation of electively aborted fetuses with sex chromosome disorders and their placentas, in parallel with analyses of epigenetic alterations and changes in gene expression in these fetuses and their placentas, with the aims to: 1. delineate how variations in sex chromosome number affect the epigenetic and genetic mechanisms regulating gene expression in the placenta and in multiple fetal tissues in fetuses with sex chromosome disorders; 2. identify the epigenetic and genetic mechanisms and placental and fetal alterations that underlie the phenotypic manifestations observed in fetuses with sex chromosome disorders.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-12-12.
Trial Details
NCT Number NCT07304193
Lead Sponsor University of Aarhus
Collaborators: Aarhus University Hospital
Conditions Sex Chromosome Disorders
Enrollment 120 participants
Start Date 2024-01-01
Primary Completion 2029-12-31 (estimated)
Study Completion 2029-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-01-08