Clinical Trial

Effects of Inspiratory vs Expiratory Breath-Hold on Lung Perfusion Measured by EIT Saline Indicator Method: A Self-Controlled Study

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Summary
This study aims to compare lung perfusion distribution between inspiratory breath-hold and expiratory breath-hold phases using the saline indicator method combined with electrical impedance tomography (EIT). A self-controlled crossover design will be used in which each participant undergoes both breath-hold conditions with standardized rapid intravenous saline injections. The primary objective is to evaluate changes in global and regional pulmonary perfusion under different lung volume states. The findings may improve understanding of perfusion redistribution with lung inflation and support optimized ventilatory strategies in clinical practice.
Trial Details
NCT Number NCT07303972
Lead Sponsor Shanghai Zhongshan Hospital
Conditions Lung Perfusion, Respiratory Physiology, Electrical Impedance Tomography, Ventilation-Perfusion Mismatch
Enrollment 100 participants
Start Date 2026-01-01
Primary Completion 2027-01-01 (estimated)
Study Completion 2028-01-01 (estimated)
Updated on ClinicalTrials.gov 2025-12-26