Genes Associated With Bone Metabolism in the Saliva During Orthodontic Treatment

Understanding the biological events during fixed orthodontic treatment is essential for optimizing treatment strategies, predicting patient response, and minimizing adverse effects. Most studies on bone remodeling have used invasive sampling methods such as tissue biopsies or serum collection; these methods cannot be used for routine clinical monitoring. Saliva is a simple medium that can reflect changes in local periodontal and bone conditions, it is also non-invasive and cheap. There is little evidence about the temporal expression of genes related to bone metabolism (RANKL, OPG, ALP, TRAP, RUNX2) in saliva during orthodontic therapy. This study will help advance the understanding of biological responses during orthodontic tooth movement and explore whether saliva can be an appropriate diagnostic medium for monitoring bone remodeling in orthodontic patients

NCT Number	NCT07303647
Lead Sponsor	Kurdistan Higher Council of Medical Specialties
Conditions	Gene Expression Profiling, Orthodentic Appliances
Enrollment	24 participants
Start Date	2025-10-12
Primary Completion	2026-02 (estimated)
Study Completion	2026-02 (estimated)
Updated on ClinicalTrials.gov	2025-12-26