Multicenter Clinical Randomized Controlled Trial of Unilateral Biportal Endoscopic Spinal Surgery for Degenerative Grade 1 Spondylolisthesis Complicated With Lumbar Spinal Stenosis

The research objective of this project is to clarify and compare the efficacy of the unilateral biportal endoscopy (UBE) technique and traditional open decompression, fusion and internal fixation surgery in the treatment of patients with Grade Ⅰ degenerative spondylolisthesis complicated with central spinal canal stenosis through high-quality, prospective, multicenter randomized controlled trials (RCTs), so as to provide high-level clinical research evidence for the expansion of UBE technique indications and its technical promotion.

NCT Number	NCT07303348
Lead Sponsor	Changhai Hospital Collaborators: Shanghai Changzheng Hospital, Shanghai Kaiyuan Orthopedic Hospital, Beijing Jishuitan Hospital, Guangzhou General Hospital of Guangzhou Military Command, Eastern Theater Command Naval Hospital
Conditions	Lumbar Spinal Stenosis (LSS), Degenerative Spondylolisthesis G1
Enrollment	200 participants
Start Date	2025-07-01
Primary Completion	2026-12-30 (estimated)
Study Completion	2027-08-01 (estimated)
Updated on ClinicalTrials.gov	2025-12-24