Aortic No-Touch vs Partial Aortic Clamping in Off-Pump CABG

To explore surgical strategies that reduce perioperative neurologic complications in cardiovascular surgery, with the aim of improving perioperative outcomes and quality of life while reducing the socioeconomic burden. Specifically: This multicenter, randomized controlled clinical trial will evaluate the benefits of a novel aortic no-touch technique in reducing perioperative silent brain infarction(SBI) among patients undergoing surgical treatment for coronary artery disease. The findings are expected to provide a safe and effective myocardial revascularization strategy for individuals at high risk of cerebral ischemia.

NCT Number	NCT07302659
Lead Sponsor	China National Center for Cardiovascular Diseases
Conditions	Coronary Artery Bypass Graft (CABG)
Enrollment	380 participants
Start Date	2026-03-10
Primary Completion	2027-12-31 (estimated)
Study Completion	2028-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-14