Clinical Trial

High-intensity Resistance Training in Post-exacerbation COPD

Recruiting
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Summary
After a COPD exacerbation, many individuals experience severe weakness in the leg muscles, especially the quadriceps. This weakness can make daily activities difficult and slow down recovery. Traditional respiratory rehabilitation usually focuses on endurance training, which is effective but often hard to tolerate soon after an exacerbation due to persistent symptoms and limited functional capacity. This study aims to compare two early rehabilitation approaches during recovery from a COPD exacerbation: a maximal strength training (MST) programme using high loads and few repetitions, and a traditional endurance-based training programme. The investigators aim to determine whether MST is easier to tolerate, especially in terms of breathlessness, and whether MST can improve muscle strength, efficiency, and overall exercise tolerance as well as or better than endurance training. The results will help identify the most suitable rehabilitation strategy for individuals recovering from a COPD exacerbation, particularly for those who struggle with high-intensity endurance exercise.
Trial Details
NCT Number NCT07302425
Lead Sponsor Istituti Clinici Scientifici Maugeri SpA
Collaborators: Universita di Verona
Conditions COPD Exacerbation
Enrollment 64 participants
Start Date 2025-10-30
Primary Completion 2027-10 (estimated)
Study Completion 2028-05 (estimated)
Updated on ClinicalTrials.gov 2025-12-24