High-Intensity Interval or Concurrent Exercise on Oxidative Stress and Inflammation in Obese Women

Introduction: Menopause is associated with body composition change, an increase in the cardio-metabolic risk factor for oxidative stress. Nevertheless, it has been suggested that regular physical training is an effective non-pharmacological intervention to reduce oxidative stress and cardio-metabolic disorders in menopausal individuals. Therefore, the present study was conducted to compare the effects of twelve weeks of high-intensity interval training (HIIT) and concurrent (Conc) and on body composition, cardio-metabolic indices and oxidative stress in sedentary obese postmenopausal women. Materials and methods: Forty-five menopausal obese women voluntarily participated and were randomly assigned into three groups: a) HIIT (6-12×60s of high intensity training (85-95% HRMax) and then running for 60 seconds with low intensity (55-60% HRMax)), b) concurrent endurance (performed on training with 55-75% HRMax) and strength training (including two sets in eight exercise stations with 55-75% 1RM)) and c) control group. Training programs were done for twelve weeks, 3 times per week. Body composition, cardio-metabolic indices and oxidative stress markers were measured before and after twelve weeks of exercise training program.

NCT Number	NCT07302191
Lead Sponsor	University of Valladolid Collaborators: Sanidad de Castilla y León, Ministerio de Ciencia e Innovación, Spain, Fundación General Universidad de Valladolid
Conditions	Women Veterans, Obese Women, Postmenopausal, Sedentary Lifestlye
Enrollment	58 participants
Start Date	2025-09-02
Primary Completion	2025-11-20 (estimated)
Study Completion	2025-12-08 (estimated)
Updated on ClinicalTrials.gov	2025-12-31