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A Research Study to Look at the Effect of Ziltivekimab on Plaque in the Blood Vessels of the Heart, Compared to Placebo, in People With a Heart Attack

Study acronym: ZEPHYR
StatusRecruiting
PhasePhase 3
Started2025-12-18
View on ClinicalTrials.gov ↗
The study is testing the effect of ziltivekimab on reducing plaque in the blood vessels of the heart, specifically aiming to manage or reduce atherosclerotic plaque. The purpose of the study is to determine whether ziltivekimab can effectively reduce this plaque. Participants will either receive ziltivekimab (the active medicine) or a placebo (a dummy medicine with no effect on the body), with the treatment assignment decided by chance. It is important to note that ziltivekimab is not yet approved in any country or region worldwide; therefore, it is a new medicine that doctors cannot prescribe. The study will last for about 15 months.

Amendment record

Amended 2 times since 2025-12-22; most recent filed 2026-03-10. Every amendment is listed below.

Dates here are the day the sponsor filed the amendment, not the day ClinicalTrials.gov published it. Version history last read from ClinicalTrials.gov on 2026-08-30.

2026-03-10
Amendment Study Status v2
2026-02-09
Amendment Study Status, Contacts/Locations v1
2025-12-22
Original filing
Trial Details
NCT Number NCT07301034
Lead Sponsor Novo Nordisk A/S
Conditions Myocardial Infarction
Enrollment 332 participants
Start Date 2025-12-18
Primary Completion 2028-11-14 (estimated)
Study Completion 2029-02-24 (estimated)
Updated on ClinicalTrials.gov 2026-03-11