Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Study 2

VISION-2 is an international, multi-site, prospective observational cohort study of 20,000 patients undergoing noncardiac surgery. Continuous biometric data will be blindly collected for the first 30 postoperative days, in hospital and at home, using Vitaliti™. Following study enrollment and baseline data collection, follow up visits will occur in-hospital, at 30-days, and 1-year post-operatively. VISION-2 has 3 primary objectives, among participants who underwent noncardiac surgery, the investigators will: 1) determine the pattern and frequency of physiological precursors (i.e., biophysical signals) to MINS, BIMS, sepsis, and infection without sepsis; 2) build prediction models from these biophysical signals and their extracted features through supervised machine learning, for the prediction and early detection of those complications; and 3) build a biobank for evaluation of novel biomarkers.

NCT Number	NCT07300579
Lead Sponsor	Hamilton Health Sciences Corporation Collaborators: McMaster University, Canadian Institutes of Health Research (CIHR), Population Health Research Institute
Conditions	Myocardial Injury After Noncardiac Surgery (MINS), Bleeding Independently Associated With Mortality After Noncardiac Surgery (BIMS), Sepsis, Infection Without Sepsis, Post-operative Complications
Enrollment	20,000 participants
Start Date	2026-06
Primary Completion	2031-06 (estimated)
Study Completion	2032-06 (estimated)
Updated on ClinicalTrials.gov	2026-04-14