Impact Of The Gut Microbiota On Host Cells Energy Metabolism in Health And In Inflammatory Bowel Disease

Inflammatory Bowel Disease (IBD) often leads to poor disease control and reduced quality of life. Changes in the gut microbiota may disrupt the energy metabolism of immune cells, contributing to IBD. This study will examine how gut microbiota affects immune cell metabolism in healthy adults and IBD patients. Healthy volunteers will be tested before and after a short antibiotic treatment, while IBD patients will be tested once. Energy metabolism will be measured using SCENITH, a method that analyzes metabolic activity in blood immune cells. Participants will also receive a special form of fiber (13C-labeled inulin) to track how gut bacteria break down and use this nutrient. Blood, urine, and stool samples will be analyzed to follow the metabolic fate of inulin. DNA and RNA from stool will be studied to identify which bacteria metabolize the labeled fiber.

NCT Number	NCT07300553
Lead Sponsor	Assistance Publique - Hôpitaux de Paris Collaborators: INSERMUMR938, CRB SAT APHP.SU Saint-Antoine hospital
Conditions	IBD, Crohn Disease, Ulcerative Colitis (UC)
Enrollment	45 participants
Start Date	2026-01-02
Primary Completion	2026-11 (estimated)
Study Completion	2027-08 (estimated)
Updated on ClinicalTrials.gov	2026-03-12