Sequential Combined Versus Single-Strategy Adrenal Venous Sampling for Primary Aldosteronism(SCOPE)

This study is a prospective, multicenter, randomized clinical trial aimed to compare the impact of three AVS diagnostic strategies on the clinical outcomes of patients with primary aldosteronism. The strategies include sequential combined AVS (non-ACTH-stimulated followed by ACTH-stimulated AVS), non- ACTH-stimulated AVS alone, and ACTH-stimulated AVS alone. The findings of this study will provide critical evidence for the clinical practice standards of AVS.

NCT Number	NCT07298954
Lead Sponsor	Shumin Yang Collaborators: First Affiliated Hospital of Kunming Medical University, The First Affiliated Hospital of Nanchang University, The People's Hospital of Chuxiong Yi Autonomous Prefecture
Conditions	Primary Aldosteronism
Enrollment	456 participants
Start Date	2025-12-25
Primary Completion	2027-12-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-24