Transforming Research and Clinical Knowledge in Geriatric Traumatic Brain Injury (TRACK-GERI)

The purpose of this study is to improve the diagnosis and prediction of recovery after traumatic brain injury (TBI) in adults age 65 years and older. The study will follow older adults who present to the emergency department after TBI, as well as matched control participants, and will measure clinical features, brain imaging, and blood-based biomarkers over 12 months to understand how recovery changes over time. Researchers will examine how pre-injury health, brain structure, and biological markers are related to disability and cognitive outcomes after TBI. Information from this study will be used to develop age-appropriate tools to better diagnose TBI and estimate long-term outcomes in older adults.

NCT Number	NCT07296783
Lead Sponsor	University of California, San Francisco Collaborators: Doris Duke Charitable Foundation, National Institute of Neurological Disorders and Stroke (NINDS), National Institute on Aging (NIA), United States Department of Defense, US Department of Veterans Affairs
Conditions	Traumatic Brain Injury
Enrollment	1,500 participants
Start Date	2019-09-02
Primary Completion	2027-01 (estimated)
Study Completion	2027-01 (estimated)
Updated on ClinicalTrials.gov	2025-12-22