Clinical Evaluation of Integrated Chinese-Western Medicine for Infertility With DOR Patients in Women Achieving Natural Pregnancy

This study aims to evaluate the superiority of an integrated traditional Chinese and Western medicine regimen ("Xiehe DOR Bushen Tongzhi Formula" + ovulation induction therapy with ovulation monitoring and timed intercourse) compared to standard treatment alone (placebo + ovulation induction therapy with ovulation monitoring and timed intercourse) in improving the natural cumulative clinical pregnancy rate in infertile patients with kidney deficiency-type diminished ovarian reserve (DOR).

NCT Number	NCT07296614
Lead Sponsor	Peking Union Medical College Hospital Collaborators: Dongfang Hospital Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Shandong University, Xiamen University, Beijing Obstetrics and Gynecology Hospital, Xiyuan Hospital of China Academy of Chinese Medical Sciences, The Third Affiliated Hospital of Beijing University of Chinese Medicine, Hunan Provincial Maternal and Child Health Care Hospital, Guangdong Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Institute of Basic Medical Sciences CAMS, First Affiliated Hospital of Heilongjiang Chinese Medicine University, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), The First Affiliated Hospital of Zhengzhou University, Shenyang Women's and Children's Hospital
Conditions	Diminished Ovarian Reserve (DOR), Infertility
Enrollment	320 participants
Start Date	2025-12-25
Primary Completion	2028-07-30 (estimated)
Study Completion	2028-07-30 (estimated)
Updated on ClinicalTrials.gov	2025-12-22