Expert Consensus on the Use of Isotretinoin in Rejuvenation: A Delphi Study

This expert consensus project explores the role of low-dose isotretinoin as a rejuvenative and preventive strategy for photoaging and sebaceous-driven skin changes. While isotretinoin is traditionally used for acne, increasing clinical experience suggests that carefully selected micro-dose and low-dose regimens may improve skin texture, pore size, sebaceous activity, and overall skin quality, with potential benefits in skin aging and maintenance rejuvenation programs.

NCT Number	NCT07296536
Lead Sponsor	Venus Research Center
Conditions	Isotretinoin, Isotretinoin Adverse Reaction, Rejuvenation
Enrollment	15 participants
Start Date	2026-01-25
Primary Completion	2027-06-01 (estimated)
Study Completion	2027-09-01 (estimated)
Updated on ClinicalTrials.gov	2025-12-22