Clinical Trial

The Asia-Pacific Mitral & Tricuspid Valve-in-Valve/Valve-in-Ring Registry

Study acronym: AP ViV
Not Yet Recruiting
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Summary
A significant number of patients with severe mitral and tricuspid valve disease have been previously treated with either valve repair with annuloplasty rings or valve replacement with bioprosthetic/mechanical valves. Over time, these bioprosthetic valves and rings may fail resulting in recurrence of the valvular disease. The technical aspects of a re-do operation are complex and these patients are often times at high risk for repeat open surgery. The emergence of transcatheter options may provide a safer and less invasive alternative to open surgery. Majority of the data currently exist for Western cohorts with limited longer-term outcomes. Data on this therapy is particularly lacking in the Asia-Pacific region, especially important in the light of known differences in body habitus and size.
Trial Details
NCT Number NCT07296016
Lead Sponsor Prince of Wales Hospital, Shatin, Hong Kong
Collaborators: National Heart Centre Singapore
Conditions Structural Heart Disease, Mitral Valve Regurgitation
Enrollment 15 participants
Start Date 2026-01-05
Primary Completion 2035-12-31 (estimated)
Study Completion 2035-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-12-22