Topical Nifedipine 0.3% Plus Lidocaine 1.5% for Uncomplicated Hemorrhoidal Disease

The goal of this observational study is to evaluate the effectiveness of topical nifedipine 0.3% plus lidocaine 1.5% for uncomplicated hemorrhoidal disease. The main question it aims to answer is: Does topical nifedipine 0.3% plus lidocaine 1.5% lower symptoms in patients with uncomplicated acute hemorrhoidal disease? Participants already taking nifedipine 0.3% plus lidocaine 1.5% as part of their regular medical care for hemorrhoidal disease will undergo four visits over a 30-day period, including two telephone contacts and two in-person visits.

NCT Number	NCT07295886
Lead Sponsor	Cardarelli Hospital Collaborators: Neopharmed Gentili S.p.A.
Conditions	Hemorrhoid Bleeding, Hemorrhoids Prolapse, Hemorrhoid Pain, Hemorrhoid, Topical Administration
Enrollment	80 participants
Start Date	2025-09-02
Primary Completion	2026-05-02 (estimated)
Study Completion	2026-05-02 (estimated)
Updated on ClinicalTrials.gov	2025-12-22