Blood Sampling Pre- and Post-Propofol Administration to Characterize the Blood Proteome Using Different Research Assays

Background: Propofol is a drug that helps people fall asleep quickly and stay asleep during surgery, so they do not feel any pain. This drug is also used to sedate critically ill people who must be on a ventilator (a machine to help them breathe). To better understand how to interpret blood tests in these ill people, researchers need to know more about how the drug itself may change proteins in the blood. Objective: To collect blood samples from people before and after propofol is administered for surgery. Eligibility: People aged 18 years or older who are scheduled for surgery that requires sedation with propofol. Design: Participants will have data collected. This data will include age, sex, and ethnicity. They will be asked about their medical history. Participants will have blood samples collected before and after they receive propofol for their surgery. The blood will be collected from lines already installed for the surgery; no new needlesticks will be done for the study. A total of 3 teaspoons of blood will be drawn. The samples will be compared to each other to look for any changes caused by the drug. No follow-up visits are required.

NCT Number	NCT07295795
Lead Sponsor	National Institutes of Health Clinical Center (CC)
Conditions	Critically Ill Surgical Patients
Enrollment	10 participants
Start Date	2026-02-10
Primary Completion	2026-02-13 (estimated)
Study Completion	2026-02-13 (estimated)
Updated on ClinicalTrials.gov	2026-04-21