Predictors of Long-Term Evolution in Long COVID; 4-Year Follow-Up. (BioICOPER Follow-up Study)

Long COVID (persistent COVID) represents a major global health challenge due to its high prevalence (approximately 7%), significant impact on quality of life, and socioeconomic burden. Despite extensive research, diagnostic tools to objectively identify or predict long COVID evolution are still lacking. The BioICOPER Follow-up Study aims to analyze the influence of biomarker evolution on clinical symptomatology (particularly chronic fatigue) and vascular health after four years of follow-up among 400 participants previously included in the original BioICOPER cohort. Advanced proteomic analysis, vascular function assessment, and machine-learning-based predictive modeling will be used to identify biomarkers associated with disease progression, stratified by sex. This project will contribute to personalized clinical management of long COVID and improved diagnostic and therapeutic strategies in primary care.

NCT Number	NCT07295483
Lead Sponsor	Instituto de Investigación Biomédica de Salamanca Collaborators: Carlos III Health Institute
Conditions	Persistent COVID Condition
Enrollment	400 participants
Start Date	2026-02-09
Primary Completion	2029-03 (estimated)
Study Completion	2029-06 (estimated)
Updated on ClinicalTrials.gov	2026-03-12