Impact of Lifestyle Interventions on Cognitive Decline in Non-alcoholic Fatty Liver Disease

This study investigates whether a structured lifestyle program can help improve thinking skills and liver health in adults with Non-Alcoholic Fatty Liver Disease (NAFLD). We are enrolling 45 participants, aged 18-42, who will be randomly assigned to one of three groups for six months: one receiving general health advice, a second following a supervised Mediterranean diet plan, and a third combining the same diet with a regular walking program. The main goal is to see if these diet and exercise interventions can lead to better scores on memory and reasoning tests, reduce liver stiffness measured by a painless scan (FibroScan), and improve related blood markers of inflammation and hormone balance.

NCT Number	NCT07294963
Lead Sponsor	Khyber Medical University Peshawar Collaborators: Northwest General Hospital and Research centre, Khyber Teaching Hospital
Conditions	Non-Alcoholic Fatty Liver Disease, Neurocognitive Disorders
Enrollment	45 participants
Start Date	2025-10-01
Primary Completion	2026-04-28 (estimated)
Study Completion	2026-06-15 (estimated)
Updated on ClinicalTrials.gov	2025-12-19