Clinical Trial

Comparison of Intrathecal Nalbuphine Versus Intrathecal Tramadol as Adjuvants in Subarachnoid Block for Lower Limb Orthopaedic Surgeries

Active, Not Recruiting
View on ClinicalTrials.gov →
Record status
This record was last updated March 18, 2026 (before its estimated July 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
This study compares the use of intrathecal nalbuphine versus intrathecal tramadol as adjuvant agents to local anaesthetics in subarachnoid block for lower-limb orthopaedic surgeries. The primary objective is to determine whether there is a meaningful difference between the two drugs in terms of quality and duration of intraoperative and postoperative analgesia. Secondary outcomes include onset and efficacy of sensory and motor block, time to first rescue analgesia, incidence of adverse effects, and perioperative hemodynamic stability. By evaluating these parameters, the study aims to identify which adjuvant provides superior analgesic benefits with fewer side effects in patients undergoing lower-limb orthopedic procedures.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-12-08; most recent amendment 2026-03-17.
Status change: Not Yet Recruiting → Active, Not Recruiting 2026-03-17
Trial Details
NCT Number NCT07294352
Lead Sponsor CMH Lahore Medical College and Institute of Dentistry
Conditions Adjuvants, Anesthesia, Subarachnoid Block
Enrollment 40 participants
Start Date 2026-01-01
Primary Completion 2026-07-01 (estimated)
Study Completion 2026-08-01 (estimated)
Updated on ClinicalTrials.gov 2026-03-18