Incidence and Risk Factors of Post-Induction Hypotension in Geriatric Cancer Patients

This observational clinical study aims to investigate the incidence and risk factors of post-induction hypotension (PIH) in geriatric cancer patients undergoing surgery under general anesthesia. PIH is defined as a drop in mean arterial pressure of ≥30% from baseline or below 65 mmHg within the first 20 minutes after anesthesia induction, prior to surgical stimulation. The primary objective is to determine the frequency of PIH in elderly oncology patients. Secondary objectives include evaluating the association of PIH with age, ASA score, cancer type, oncological treatments (chemotherapy/radiotherapy), comorbidities, medication use, anemia, biochemical parameters, and preoperative perfusion index (PI) and pleth variability index (PVI). Findings from this study are expected to contribute to improved perioperative management and to the development of tailored anesthesia protocols for geriatric oncology patients.

NCT Number	NCT07294040
Lead Sponsor	Dolunay ARIK
Conditions	Post-induction Hypotension (PIH), Geriatric Patient, Oncologic Disease, Hemodynamic Effects of General Anesthesia, Risk Factors Associated With Anesthesia-Induced Hypotension
Enrollment	140 participants
Start Date	2025-05-25
Primary Completion	2026-05-25 (estimated)
Study Completion	2026-05-25 (estimated)
Updated on ClinicalTrials.gov	2025-12-19