Clinical Trial

Ultrasound Neuroimmune Modulation in Adults With Rheumatoid Arthritis

Study acronym: SUSTAIN
Recruiting
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Summary
This two-stage, multicenter clinical trial is designed to evaluate the feasibility, safety, and preliminary efficacy of splenic ultrasound stimulation to activate immune-neuromodulation (SUSTAIN) in patients with rheumatoid arthritis (RA) and at least moderate disease activity. The findings from this trial will directly inform the design and power calculations for a future pivotal trial by identifying an appropriate effect size and confirming protocol feasibility and safety.
Protocol Amendment History 4 changes
critical Phase changed: Phase 2 -> not applicable 2026-07-08
critical Primary endpoint(s) modified 2026-07-08
notable Primary completion pushed: 2026-12 -> 2027-01 2026-07-08
minor Completion moved earlier: 2027-07 -> 2027-04 2026-07-08
Trial Details
NCT Number NCT07293871
Lead Sponsor Surf Therapeutics
Conditions Rheumatoid Arthritis
Enrollment 40 participants
Start Date 2026-03-20
Primary Completion 2027-01 (estimated)
Study Completion 2027-04 (estimated)
Updated on ClinicalTrials.gov 2026-07-07