Clinical Trial

PREcision MEDicine In Achalasia (PREMEDIA) - Cohort

Study acronym: PREMEDIA
Recruiting
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Summary
The goal of this observational study is to learn about how the doctor decides how long to cut t the esophageal muscle during Per-Oral Endoscopic Myotomy (POEM) in patients with difficulty swallowing due to certain conditions. The main question it aims to answer is: does pre-POEM testing help the physician choose how long to cut the muscle. Participants will allow researchers to access their standard of care information in their medical record, complete questionnaires at up to 6 times over a 2-year period.
Protocol Amendment History 3 changes
notable Primary completion pushed: 2029-05-01 -> 2031-08-31 2026-07-22
minor Completion pushed: 2030-03-01 -> 2032-08-31 2026-07-22
critical Recruitment opened 2026-05-21
Trial Details
NCT Number NCT07293689
Lead Sponsor Northwestern University
Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions Type III Achalasia, EGJ Outflow Obstruction With Spastic/Hypercontractile Features, Jackhammer Esophagus, Distal Esophageal Spasm
Enrollment 200 participants
Start Date 2026-12-01
Primary Completion 2031-08-31 (estimated)
Study Completion 2032-08-31 (estimated)
Updated on ClinicalTrials.gov 2026-08-07