Understanding Practices of Lactation and Infant Feeding Together With Women With HIV in the United States

IMPAACT 2046/UPLIFT (Understanding Practices of Lactation and Infant Feeding decisions Together with women with HIV) is a multi-site, mixed-methods, observational cohort study. The purpose of the study is to explore infant feeding preferences, practices, and outcomes among mothers with HIV and their families in the United States. It will employ both qualitative and quantitative research methods to address existing knowledge gaps and to understand the clinical, behavioral, and social factors influencing infant feeding decisions. As part of the study's mixed method approach, a longitudinal cohort study of mothers and their infants will be established. The study also aims to pilot a national registry of breastfeeding women living with HIV in the United States.

NCT Number	NCT07293559
Lead Sponsor	International Maternal Pediatric Adolescent AIDS Clinical Trials Group Collaborators: University of Colorado, Denver, Centers for Disease Control and Prevention, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute of Allergy and Infectious Diseases (NIAID)
Conditions	HIV-1-infection, Breastfeeding, Pregnancy Related
Enrollment	1,150 participants
Start Date	2026-02-24
Primary Completion	2031-04-24 (estimated)
Study Completion	2031-04-24 (estimated)
Updated on ClinicalTrials.gov	2026-03-27