DEGIMTNCT07292974

Endothelial Glycocalyx and Inflammatory Response Changes in Acute Stroke Patients Undergoing Mechanical Thrombectomy

StatusEnrolling by Invitation

PhaseNot specified

SponsorClinical Hospital Centre Zagreb

Primary completionDec 2028 (estimated)

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Record History

All 2 versions: 2 with changes below. See every version on ClinicalTrials.gov ↗

Notable Nov 9, 2026 Enrolling by invitation only Show 4 more changesShow less
- Start date changed from estimate of Jan 2026 to Jul 15, 2026
- Eligibility criteria shortened, about 15 words
- Primary endpoints: details revised at 1 of 2 entries
- Study title shortened, about 1 word
Dec 5, 2025 Study First Submitted

Notable: the plan changed

Endpoints

Primary

Concentrations of EG degradation products (syndecan 1, heparan sulfate) and the neovascularization factor VEGF in peripheral blood during the intervention and 24 hours after revascularization/attempted revascularization.

Timeframe: 24 hours

Cytokine concentrations (IL 6, IL 10)

Timeframe: 24 hours

Arms and interventions

Acute stroke patients

MT/ MT + thrombolysis/ thormbolysis only

Procedures: Mechanical thrombectomy

Sites

1 site in 1 country

University Hospital Center ZagrebZagreb, Croatia

About this trial

Ischemic stroke (IS) is one of the leading causes of mortality and disability. Treatment of IS is based on reperfusion methods, thrombolysis and mechanical thrombectomy (MT). However, there are significant limitations in their implementation and success. Also, there is a mismatch between successful recanalization of the blood vessel, recovery of the neurological status as well as treatment outcome. Precisely for these reasons, there is a need for a better understanding of pathophysiology events in the acute IS and for the development of new therapeutic procedures that would include neuroprotection, modification of the inflammatory response and preservation of the integrity of the blood-brain barrier. Acute IS occurs as a result of a blood vessel blockage, which leads to ischemic damage to the brain parenchyma. It causes an early inflammatory response that is extremely complex, involving a large number of inflammatory cytokines whose dynamics and role in the pathophysiology of IS are insufficiently investigated. It is known that inflammatory processes damage the endothelial glycocalyx (EG), a thin luminal layer of the endothelium that has numerous functions such as maintaining the integrity of blood vessels and regulating tone, and itself participates in the inflammatory response. In the brain, EG is a key regulator of the integrity of the blood-brain barrier, and its damage makes the barrier more permeable, which can lead to edema and the passage of potentially harmful substances. Clinical studies have shown that there is a possible relationship between the prognosis of patients with IS and the concentration of EG breakdown products in the peripheral blood. However, the relationship between changes in EG and the inflammatory process in the context of IS, and especially in relation to available treatment methods, remains unclear. The aim of the proposed study is to determine and analyze the dynamics of concentrations of EG degradation products and inflammatory cytokines in patients with acute IS during and after MT. This study would include all adult patients with acute IS who will undergo MT, and the concentrations of EG degradation products and inflammatory cytokines would be determined by the enzyme immunoassay method from peripheral blood and blood samples from the cerebral circulation after reperfusion. The obtained results will be correlated with the collected data on the neurological condition of the patient before and after the intervention, the type and course of the intervention performed, the course and duration of hospital treatment, the occurrence of complications and the outcome of treatment.

Trial details

Enrollment: 150 participants (estimated)
Started: Jul 15, 2026
Study completion: Oct 2030 (estimated)
Eligibility: 18 and older, all sexes, healthy volunteers accepted
Design: Observational
Oversight: No data monitoring committee
Conditions: Stroke, Thrombectomy, Endothelial Glycocalyx
Collaborators: University Hospital Rijeka, University of Rijeka
Official title: Dynamic Changes of Endothelial Glycocalyx and Inflammatory Response in Acute Stroke Patients Treated With Mechanical Thrombectomy
First posted: Dec 18, 2025
Registry updated: Nov 13, 2026
Last verified: Nov 2026

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