Inflammation-Related Endothelial Barrier Dysfunction in Patients With Apical Periodontitis

Inflammation is a common factor in chronic periodontitis and systemic diseases. However, to date, there is no scientific evidence supporting a causal effect of inflammation caused by apical periodontitis on endothelial barrier dysfunction. A case-control study was designed to evaluate serum levels of endothelial barrier dysfunction factors in a sample of healthy patients aged 25 to 55, with or without apical periodontitis, before endodontic treatment and 6 and 12 months after treatment. The aim of this study is to investigate the potential relationship between the presence of chronic endodontic lesions and inflammation-related alterations of the endothelial barrier that may compromise its integrity, as well as to determine whether endodontic treatment can reduce these factors, thereby preventing changes in endothelial permeability.

NCT Number	NCT07292363
Lead Sponsor	University of Turin, Italy
Conditions	Apical Periodontitis, Healhty
Enrollment	45 participants
Start Date	2021-02-09
Primary Completion	2022-04-30 (estimated)
Study Completion	2025-10-16 (estimated)
Updated on ClinicalTrials.gov	2025-12-31