Clinical Trial

Pain Perception and Exercise-Induced Hypoalgesia Across Circadian Rhythms

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Record status
This record was last updated December 18, 2025 (before its estimated March 2026 completion). Its status may not reflect the trial's current state.
Summary
The goal of this randomized crossover clinical trial is to investigate whether exercise-induced hypoalgesia (EIH) is influenced by circadian rhythm in healthy adults aged 18-40 years. The main questions it aims to answer are: * Does the time of day (morning vs. evening) influence changes in pain perception following exercise? * Do chronotype, sex, or stimulation site (bony vs. muscular) alter the magnitude of this effect? Participants will: * Complete questionnaires * Undergo quantitative sensory testing * Attend both morning and evening sessions in randomized crossover order
Trial Details
NCT Number NCT07290465
Lead Sponsor Medipol University
Conditions Exercise Induced Hypoalgesia, Circadian Rhythm, Pain Perception, Healthy Participants, Chronotype, Physical Therapy
Enrollment 56 participants
Start Date 2026-01
Primary Completion 2026-03 (estimated)
Study Completion 2026-04 (estimated)
Updated on ClinicalTrials.gov 2025-12-18