Protocolised Management of Phosphate Replacement Trial

The aim of this cluster, crossover, randomised controlled trial is to compare two standard arms of treatment for the replacement of phosphate in critically ill patients. We hypothesise that protocolised restricted phosphate replacement, compared to protocolised liberal phosphate replacement, will result in reduced administration of phosphate with similar clinical outcomes. All eligible Intensive Care Unit (ICU) patients will be included during their admission with the selected protocol for that period as per usual practice and treatment standards.

NCT Number	NCT07288944
Lead Sponsor	Caboolture Hospital Collaborators: Queensland University of Technology
Conditions	Phosphate Deficiency, Hypophosphatemia, Protocol Optimization, Critical Care, Intensive Care
Enrollment	2,400 participants
Start Date	2026-01
Primary Completion	2027-02 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2025-12-17