Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II

After severe traumatic brain injury, adequate blood flow to the brain is essential for recovery. This depends on arterial blood pressure, yet intensive care units apply fixed targets to all patients - treating every brain and patient the same. This study aims to change that. With new technology, 'optimal' blood pressure can be determined for each individual brain and treatment can be tailored accordingly. This personalized approach to neurocritical care has never been tested in a randomized controlled study before. If effective in showing reduced brain damage biomarkers, it will fundamentally transform brain injury treatment and dramatically improve recovery outcomes for patients worldwide.

NCT Number	NCT07287358
Lead Sponsor	Maastricht University Medical Center Collaborators: Medisch Spectrum Twente, Radboud University Medical Center, Medical Center Haaglanden
Conditions	Traumatic Brain Injury, Severe Traumatic Brain Injury, Intracranial Pressure, Cerebral Perfusion Pressure
Enrollment	60 participants
Start Date	2026-05-01
Primary Completion	2028-05-01 (estimated)
Study Completion	2028-05-15 (estimated)
Updated on ClinicalTrials.gov	2026-01-06