Clinical Trial

Stereotactic Body Radiotherapy With Sequential Iparomlimab and Tuvonralimab (QL1706) + Chemotherapy as Neoadjuvant Therapy in Patients With Resectable Non-small-cell Lung Cancer in China (LUNG-Nanjing01): a Single-arm, Single-centre, Phase 2 Trial

Not Yet Recruiting Phase 2
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Summary
The primary objective of this study is to evaluate whether neoadjuvant SBRT as an immunomodulator in combination with apalolimab and toripalimab (QL1706) plus chemotherapy improves the pathological complete response (pCR) rate in patients with resectable stage IIA-IIIB LUAD. The secondary objectives include major pathological response (MPR), disease-free survival (DFS), R0 resection rate, the feasibility and safety. Moreover, the potential predictors for pathological response also will be explored.
Trial Details
NCT Number NCT07286942
Lead Sponsor Jiangsu Cancer Institute & Hospital
Conditions NSCLC, NSCLC (Non-small Cell Lung Cancer)
Enrollment 24 participants
Start Date 2025-12-18
Primary Completion 2027-12-18 (estimated)
Study Completion 2029-12-18 (estimated)
Updated on ClinicalTrials.gov 2025-12-16