Effect of Misoprostol on Fluid Deficit Volume in Hysteroscopic Myomectomy

The goal of this double blinded randomized control trial is to evaluate the impact of misoprostol on fluid deficit during hysteroscopic myomectomies. The main questions it aims to answer are: Is there is difference in fluid deficit in patients who receive misoprostol vs placebo pre operatively for hysteroscopic myomectomies? Participants will be randomized to received 800 mcg of either rectal misoprostol prior to their hysteroscopic myomectomy or 4 tablets of placebo (ZEEBO) prior to their hysteroscopic myomectomy.

NCT Number	NCT07286188
Lead Sponsor	Northwestern University
Conditions	Fibroids, Uterine, Fluid Deficit, Hysteroscopy / Methods
Enrollment	40 participants
Start Date	2025-12-16
Primary Completion	2026-12 (estimated)
Study Completion	2026-12 (estimated)
Updated on ClinicalTrials.gov	2026-06-01