Clinical Trial

Stereotactic Body RadioTherapy With Continuous Tracking for Primary and Secondary Renal Cancer

Study acronym: SBRTRC
Not Yet Recruiting
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Summary
This is a prospective, interventional, monocentric, clinical study of Stereotactic Body Radiation Therapy (SBRT) for primary or secondary renal tumors, delivering from 25-26 Gy/1 fraction to 42-48 Gy/3-4 fractions or 40-50 Gy/5 fractions (standard prescriptions for the internationl guidelines, according to tumor size), using a robotic accelerator -CyberKnife® (Accuray, Sunnyvale, CA)-, with fiducial-tracking, to observe the acute and late toxicity reduction (as primary objectives), due to the maximum precision of the treatment. Secondary objectives are Local Relpase-Free Survival (LRFS), Regional Relapse-Free Survival (RRFS), Distant Metastasis-Free Survival (DMFS), Disease-Free Survival (DFS), Cancer Specific Survival (CSS), Overall Survival (OS) and Quality-of-Life (QoL). A total of 60 participants are expected to be enrolled over four years, and the follow-up of enrolled patients will be three years.
Trial Details
NCT Number NCT07285538
Lead Sponsor IRCCS San Raffaele
Conditions Renal Cancer, Renal Secondary Cancer, Stereotactic Body Radiotherapy
Enrollment 60 participants
Start Date 2026-01-15
Primary Completion 2033-01-15 (estimated)
Study Completion 2033-01-15 (estimated)
Updated on ClinicalTrials.gov 2025-12-16