Clinical Trial

Regenarative Treatment of Periocular Wrinkles With PDRN

Active, Not Recruiting
View on ClinicalTrials.gov →
Record status
This record was last updated May 18, 2026 (before its estimated May 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
This randomized clinical trial aims to compare two application techniques-needling (intradermal needling) and microneedling-for the delivery of an active-ingredient formulation containing 0.2% polynucleotides (PDRN), 2% hyaluronic acid, and 0.1% niacinamide for the treatment of periocular wrinkles related to aging.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-12-09; most recent amendment 2026-05-15.
Status change: Recruiting → Active, Not Recruiting 2026-05-15
Status change: Enrolling by Invitation → Recruiting 2025-12-16
Trial Details
NCT Number NCT07280637
Lead Sponsor University of Taubate
Collaborators: Cavalca & Cortelli private research center
Conditions Skin Wrinklings
Enrollment 25 participants
Start Date 2025-11-30
Primary Completion 2026-05-30 (estimated)
Study Completion 2026-06-10 (estimated)
Updated on ClinicalTrials.gov 2026-05-18